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Human Insulin (INS) Protein
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Catalogue No: abx060195
Price:
US$348.00
(Size: 1 mg)
Orders to United States ship from United States
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Human Insulin (INS) Protein is a recombinant protein expressed in E. coli. Limited solubility at neutral pH and physiological salt concentrations. Insulin, synthesized by the beta cells of the islets of Langerhans, consists of 2 polypeptide chains, A and B, which are linked by disulfide bonds. The Human insulin gene contains 3 exons; exon 2 encodes the signal peptide, the B chain, and part of the C peptide, while exon 3 encodes the remainder of the C peptide and the A chain. Insulin has a potent acute antiinflammatory effect, including a reduction in intranuclear NF-kappa-B, an increase in IKB, and decreases in the generation of reactive oxygen species. It causes cells in the liver, muscle, and fat tissue to take up glucose from the blood, storing it as glycogen inside these tissues, and improved insulin-stimulated glucose uptake after endurance training results from hemodynamic adaptations as well as increased cellular protein content of individual insulin signaling components and molecules involved in glucose transport and metabolism.
Research Articles on Insulin (INS)
| Target | Insulin (INS) |
| Origin | Human |
| Expression | Recombinant |
| Tested Applications | ELISA, SDS-PAGE |
| Host | E. coli |
| Conjugation | Unconjugated |
| Form | Liquid |
| Purity | > 95% (SDS-PAGE) |
| Storage | Aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P01308 (UniProt, ExPASy) |
| UniProt Secondary AC | Q5EEX2 |
| UniProt Entry Name | INS_HUMAN |
| GeneID | 3630 |
| OMIM | 176730 |
| KEGG | hsa:3630 |
| String | 9606.ENSP00000380432 |
| Sequence Fragment | Full length Human Insulin (INS) Protein. |
| Buffer | 10 mM Glycin buffer, pH 3.5 with 0.1% NaN3. |
| Biological Activity | 25 IU/mg |
| Concentration | 4.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |