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SET Domain Bifurcated 1 (SETDB1) Antibody
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Catalogue No: abx004701
Price:
US$232.00
(Size: 20 µl)
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![Western blot analysis of lysates from wild type (WT) and SETDB1 knockout (KO) 293T cells, using [KO Validated] SETDB1 Antibody at 1/1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) at 1/10000 dilution. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Exposure time: 30s.](https://www.abbexa.com/image/cache/data/products/18B/abx004701_1-500x500.jpg "SET Domain Bifurcated 1 (SETDB1) Antibody")
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SETDB1 Antibody is a Rabbit Polyclonal antibody against SETDB1. This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.
Research Articles on SET Domain Bifurcated 1 (SETDB1)
| Target | SET Domain Bifurcated 1 (SETDB1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-397 of human SETDB1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q15047 (UniProt, ExPASy) |
| UniProt Secondary AC | A6NEW2, Q5SZD8, Q5SZD9, Q5SZE0, Q5SZE7, Q96GM9 |
| UniProt Entry Name | SETB1_HUMAN |
| Gene Symbol | SETDB1 |
| GeneID | 9869 |
| NCBI Accession | NP_001230420.1 |
| KEGG | hsa:9869 |
| String | 9606.ENSP00000271640 |
| Molecular Weight | Calculated MW: 143 kDa Observed MW: 180 kDa |
| Buffer | PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol. |
| Concentration | 2.52 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |