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Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Antibody
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Catalogue No: abx003676
Price:
US$217.50
(Size: 20 µl)
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TDP1 Antibody is a Rabbit Polyclonal antibody against TDP1. The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
Research Articles on Tyrosyl-DNA Phosphodiesterase 1 (TDP1)
| Target | Tyrosyl-DNA Phosphodiesterase 1 (TDP1) |
| Clonality | Polyclonal |
| Reactivity | Human, Rat |
| Tested Applications | ELISA, WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human TDP1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9NUW8 (UniProt, ExPASy) |
| UniProt Secondary AC | Q2HXX4, Q86TV8, Q96BK7, Q9NZM7, Q9NZM8 |
| UniProt Entry Name | TYDP1_HUMAN |
| Gene Symbol | TDP1 |
| GeneID | 55775 |
| NCBI Accession | NP_060789.2 |
| String | 9606.ENSP00000337353 |
| Molecular Weight | Calculated MW: 68 kDa Observed MW: 70 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |