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ABL1 (pY412) Antibody
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Catalogue No: abx000351
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US$232.00
(Size: 20 µl)
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Datasheet SDS
ABL1 (pY412) Antibody is a Rabbit Polyclonal antibody against ABL1 (pY412). The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.
Research Articles on ABL1 (pY412)
| Target | ABL1 (pY412) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, IHC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic phosphorylated peptide around Y412 of human ABL1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P00519 (UniProt, ExPASy) |
| UniProt Secondary AC | A3KFJ3, Q13869, Q13870, Q16133, Q17R61, Q45F09 |
| UniProt Entry Name | ABL1_HUMAN |
| Gene Symbol | ABL1 |
| GeneID | 25 |
| OMIM | 189980 |
| NCBI Accession | NP_009297.2 |
| HGNC | 76 |
| KEGG | hsa:25 |
| Ensembl | ENSG00000097007 |
| String | 9606.ENSP00000361423 |
| Molecular Weight | Calculated MW: 123 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 2.75 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |