ABL1 (pY412) Antibody

Catalogue No: abx000351
Price: $308.00
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ABL1 (pY412) Antibody
ABL1 (pY412) Antibody

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ABL1 (pY412) Antibody is a Rabbit Polyclonal antibody against ABL1 (pY412). The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.

Target ABL1 (pY412)
Reactivity Human, Mouse
Origin Human
Host Rabbit
Clonality Polyclonal
Tested Applications IHC, IF/ICC
Recommended dilutions IHC: 1/50 - 1/100, IF/ICC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Y412 of human ABL1.
Purification Affinity purified.
Isotype IgG
Conjugation Unconjugated
Storage Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Molecular Weight 122 kDa
Swiss Prot P00519
GeneID 25
Gene Symbol ABL1
OMIM 189980
HGNC 76
Ensembl ENSG00000097007
Concentration > 1 mg/ml
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Availability Shipped within 5-10 working days.
Note This product is for research use only.

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