RAC-Beta Serine/Threonine-Protein Kinase Phospho-Ser474 (AKT2 pS474) Antibody

AKT2 (pS474) Antibody is a Rabbit Polyclonal antibody against AKT2 (pS474). This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins.

Target	RAC-Beta Serine/Threonine-Protein Kinase Phospho-Ser474 (AKT2 pS474)
Clonality	Polyclonal
Target Modification	Ser474
Modification	Phosphorylation
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic phosphorylated peptide around S474 of human AKT2.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P31751 (UniProt, ExPASy)
UniProt Secondary AC	B2RBD8, Q05BV0, Q0VAN0, Q0VAN1, Q68GC0
UniProt Entry Name	AKT2_HUMAN
Gene Symbol	AKT2
GeneID	208
NCBI Accession	NP_001617.1
KEGG	hsa:208
String	9606.ENSP00000375892
Molecular Weight	Calculated MW: 56 kDa Observed MW: 60 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on RAC-Beta Serine/Threonine-Protein Kinase Phospho-Ser474 (AKT2 pS474)

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