Complement Factor B (CFB) Antibody
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Catalogue No: abx001430
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US$348.00
(Size: 60 µl)
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Datasheet SDS
CFB Antibody is a Rabbit Polyclonal antibody against CFB. This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.
Research Articles on Complement Factor B (CFB)
| Target | Complement Factor B (CFB) |
| Research Area | Infection Immunity, Immunology, Hematology, Autoimmunity |
| Clonality | Polyclonal |
| Reactivity | Mouse, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human CFB |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P00751 (UniProt, ExPASy) |
| UniProt Entry Name | CFAB_HUMAN |
| Gene Symbol | CFB |
| GeneID | 629 |
| NCBI Accession | NP_001701.2 |
| KEGG | hsa:629 |
| String | 9606.ENSP00000416561 |
| Molecular Weight | Calculated MW: 68 kDa/85 kDa Observed MW: 100 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
