Complement Factor B (CFB) Antibody

Catalogue No: abx001430
Price: £120.00
(Size: 20 µl)
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CFB Antibody is a Rabbit Polyclonal antibody against CFB. This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.

Target Complement Factor B (CFB)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC, IF/ICC, IP
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200, IP: 1/20 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 80-420 of human Complement Factor B.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P00751 (UniProt, ExPASy)
UniProt Entry Name CFAB_HUMAN
Gene Symbol CFB
GeneID 629
NCBI Accession NP_001701.2
KEGG hsa:629
String 9606.ENSP00000416561
Molecular Weight Calculated MW: 68 kDa, 85 kDa
Observed MW: 86 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration 3.12 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Complement Factor B (CFB)

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