Aromatase (CYP19A1) Antibody
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Catalogue No: abx001773
Price:
US$348.00
(Size: 60 µl)
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Datasheet SDS
CYP19A1 Antibody is a Rabbit Polyclonal antibody against CYP19A1. CYP19A1(Cytochrome P450 19A1) is also named as ARO1(aromatase), CYAR, CYP19, estrogen synthase and belongs to the cytochrome P450 family. It is a terminal enzyme which transforms irreversibly androgens into estrogens and it is present in the endoplasmic reticulum of numerous tissues(PMID:16406261). The gene encodes a protein with the molecular weight between 46 kDa and 69 kDa(PMID:8129748) and the protein can be glycosylated, but the level of glycosylation does not seem to be essential for CYP19A1 activity(PMID:12606587). Brain aromatase may be neuroprotective by increasing the local estrogen levels in injured neurons so that genetic variation in the brain aromatase gene may modify the risk for AD(PMID:16767510). This antibody is specific to CYP19A1.
Research Articles on Aromatase (CYP19A1)
| Target | Aromatase (CYP19A1) |
| Research Area | Enzymes and Kinases, Tumor Immunity, Endocrinology, Hormone Metabolism, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human, Rat |
| Tested Applications | WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000 - 1/2000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human Aromatase |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P11511 (UniProt, ExPASy) |
| UniProt Secondary AC | Q16731, Q3B764, Q58FA0, Q8IYJ7 |
| UniProt Entry Name | CP19A_HUMAN |
| Gene Symbol | CYP19A1 |
| GeneID | 1588 |
| NCBI Accession | NP_000094.2 |
| KEGG | hsa:1588 |
| String | 9606.ENSP00000379683 |
| Molecular Weight | Calculated MW: 24 kDa/57 kDa Observed MW: 48 kDa |
| Buffer | PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
