High Affinity Nerve Growth Factor Receptor (NTRK1) Antibody
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Catalogue No: abx015714
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US$427.75
(Size: 100 µl)
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Datasheet SDS
TrkA, also known as NTRK1, MTC, TRK, TRK1.It is a member of the neurotrophic tyrosine kinase receptor (NTKR) family.This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway.The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes.Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Research Articles on High Affinity Nerve Growth Factor Receptor (NTRK1)
| Target | High Affinity Nerve Growth Factor Receptor (NTRK1) |
| Research Area | Signal Transduction |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IF/ICC |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant extracellular fragment of human TrkA (aa33-423) fused with hIgGFc tag expressed in HEK293 cell line. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P04629 (UniProt, ExPASy) |
| UniProt Entry Name | NTRK1_HUMAN |
| Gene Symbol | NTRK1 |
| GeneID | 4914 |
| OMIM | 164970 |
| HGNC | 8031 |
| KEGG | hsa:4914 |
| Ensembl | ENSG00000198400 |
| String | 9606.ENSP00000431418 |
| Molecular Weight | 87.4 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |