High Affinity Nerve Growth Factor Receptor (NTRK1) Antibody

TrkA, also known as NTRK1, MTC, TRK, TRK1.It is a member of the neurotrophic tyrosine kinase receptor (NTKR) family.This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway.The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes.Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.

Target	High Affinity Nerve Growth Factor Receptor (NTRK1)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, IF/ICC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant extracellular fragment of human TrkA (aa33-423) fused with hIgGFc tag expressed in HEK293 cell line.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P04629 (UniProt, ExPASy)
UniProt Entry Name	NTRK1_HUMAN
Gene Symbol	NTRK1
GeneID	4914
OMIM	164970
HGNC	8031
KEGG	hsa:4914
Ensembl	ENSG00000198400
String	9606.ENSP00000431418
Molecular Weight	87.4 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on High Affinity Nerve Growth Factor Receptor (NTRK1)

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