Histamine N-Methyltransferase (HNMT) Antibody
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Catalogue No: abx001961
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US$217.50
(Size: 20 µl)
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Datasheet SDS
HNMT Antibody is a Rabbit Polyclonal antibody against HNMT. In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
Research Articles on Histamine N-Methyltransferase (HNMT)
| Target | Histamine N-Methyltransferase (HNMT) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IF/ICC, IP |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/100, IP: 0.5 µg - 4 µg antibody per 200 µg - 400 µg extracts of whole cells. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant protein corresponding to HNMT. The exact sequence is proprietary. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P50135 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R9J3, Q546Z6, Q7Z7I2, Q8IU56, Q8WW98, Q9BRW6 |
| UniProt Entry Name | HNMT_HUMAN |
| Gene Symbol | HNMT |
| GeneID | 3176 |
| NCBI Accession | NP_008826.1 |
| KEGG | hsa:3176 |
| String | 9606.ENSP00000280097 |
| Molecular Weight | Calculated MW: 33 kDa Observed MW: 33 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |