Mitogen-Activated Protein Kinase 10 / JNK3 (MAPK10) Antibody
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Catalogue No: abx001724
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US$348.00
(Size: 60 µl)
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Datasheet SDS
MAPK10 Antibody is a Rabbit Polyclonal antibody against MAPK10. The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Research Articles on Mitogen-Activated Protein Kinase 10 / JNK3 (MAPK10)
| Target | Mitogen-Activated Protein Kinase 10 / JNK3 (MAPK10) |
| Research Area | Enzymes and Kinases, Infection Immunity |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide corresponding to human JNK3 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P53779 (UniProt, ExPASy) |
| UniProt Secondary AC | A6NFS3, A6NG28, B3KQ94, Q15707, Q49AP1 |
| UniProt Entry Name | MK10_HUMAN |
| Gene Symbol | MAPK10 |
| GeneID | 5602 |
| NCBI Accession | NP_620448.1 |
| KEGG | hsa:5602 |
| String | 9606.ENSP00000352157 |
| Molecular Weight | Calculated MW: 48 kDa/52 kDa Observed MW: 52 kDa |
| Buffer | PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
