Mitogen Activated Protein Kinase 10 / JNK3 (MAPK10) Antibody

Catalogue No: abx001724
Price: £120.00
(Size: 20 µl)
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MAPK10 Antibody is a Rabbit Polyclonal antibody against MAPK10. The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Target Mitogen Activated Protein Kinase 10 (MAPK10/JNK3)
Clonality Polyclonal
Reactivity Mouse
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human MAPK10.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P53779 (UniProt, ExPASy)
UniProt Secondary AC A6NFS3, A6NG28, B3KQ94, Q15707, Q49AP1
UniProt Entry Name MK10_HUMAN
Gene Symbol MAPK10
GeneID 5602
KEGG hsa:5602
String 9606.ENSP00000352157
Molecular Weight Calculated MW: 48 kDa, 52 kDa
Observed MW: 48 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Mitogen Activated Protein Kinase 10 (MAPK10/JNK3)

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