Mitogen-Activated Protein Kinase 10 / JNK3 (MAPK10) Antibody

MAPK10 Antibody is a Rabbit Polyclonal antibody against MAPK10. The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Target	Mitogen-Activated Protein Kinase 10 / JNK3 (MAPK10)
Clonality	Polyclonal
Reactivity	Mouse
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 175-464 of human JNK3.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P53779 (UniProt, ExPASy)
UniProt Secondary AC	A6NFS3, A6NG28, B3KQ94, Q15707, Q49AP1
UniProt Entry Name	MK10_HUMAN
Gene Symbol	MAPK10
GeneID	5602
NCBI Accession	NP_620448.1
KEGG	hsa:5602
String	9606.ENSP00000352157
Molecular Weight	Calculated MW: 44 kDa Observed MW: 48 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Mitogen-Activated Protein Kinase 10 / JNK3 (MAPK10)

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