5'-Nucleotidase / CD73 (NT5E) Antibody
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Catalogue No: abx016042
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US$427.75
(Size: 100 µl)
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Datasheet SDS
5'-nucleotidase, ecto (NT5E), also known as CD73 (Cluster of Differentiation 73).Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase; EC 3.1.3.5) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP.The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane.The enzyme is used as a marker of lymphocyte differentiation.Consequently, a deficiency of NT5 occurs in a variety of immunodeficiency diseases (e.g., see MIM 102700, MIM 300300).Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate.
Research Articles on 5'-Nucleotidase / CD73 (NT5E)
| Target | 5'-Nucleotidase / CD73 (NT5E) |
| Research Area | Signal Transduction, Cardiovascular Biology |
| Clonality | Monoclonal |
| Clone | W565 |
| Reactivity | Human |
| Tested Applications | ELISA, IHC |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of NT5E expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P21589 (UniProt, ExPASy) |
| UniProt Secondary AC | B3KQI8, O75520, Q5W116 |
| UniProt Entry Name | 5NTD_HUMAN |
| Gene Symbol | NT5E |
| GeneID | 4907 |
| OMIM | 129190 |
| HGNC | 8021 |
| KEGG | hsa:4907 |
| Ensembl | ENSG00000135318 |
| String | 9606.ENSP00000257770 |
| Molecular Weight | 70 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |