Suppressors of Cytokine Signaling 3 (SOCS3) Antibody

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Catalogue No: abx000829
Price: US$217.50
(Size: 20 µl)

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Western blot analysis of lysates from RAW264.7 cells, using SOCS3 Antibody at 1/500 dilution. Raw264. 7 cells were treated by LPS (1 µg/ml) at 37 °C for 8 hours. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) at 1/10000 dilution. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Exposure time: 180s.
Suppressors of Cytokine Signaling 3 (SOCS3) Antibody Suppressors of Cytokine Signaling 3 (SOCS3) Antibody Suppressors of Cytokine Signaling 3 (SOCS3) Antibody Suppressors of Cytokine Signaling 3 (SOCS3) Antibody Suppressors of Cytokine Signaling 3 (SOCS3) Antibody Suppressors of Cytokine Signaling 3 (SOCS3) Antibody

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Datasheet SDS
SOCS3 Antibody is a Rabbit Polyclonal antibody against SOCS3. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.

Target Suppressors of Cytokine Signaling 3 (SOCS3)
Research Area Signal Transduction, Tumor Immunity, Immunology, Hepatology, Cancer
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications ELISA, WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions ELISA: 1 µg/ml, WB: 1/100 - 1/500, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic peptide corresponding to SOCS3. The exact sequence is proprietary.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Shelf Life 12 months.
UniProt Primary AC O14543 (UniProt, ExPASy)
UniProt Secondary AC O14509
UniProt Entry Name SOCS3_HUMAN
Gene Symbol SOCS3
GeneID 9021
NCBI Accession NP_003946.3
KEGG hsa:9021
String 9606.ENSP00000330341
Molecular Weight Calculated MW: 25 kDa
Observed MW: 30 kDa
Buffer PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration 1.84 mg/ml
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on Suppressors of Cytokine Signaling 3 (SOCS3)


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