Signal Transducing Adaptor Molecule (STAM) Antibody
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Catalogue No: abx031569
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US$326.25
(Size: 80 µl)
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Datasheet SDS
Stimulation of cells with cytokines initiates a signal transduction cascade involving cytokine receptors, Janus kinases (JAKs) and signal transducers and activators of transcription (STATs). STAM for 'signal-transducing adaptor molecule, induced after stimulation of cells with cytokine IL2, is a component of signal transduction downstream of JAK3.1 Human STAM cDNA cloned from a T-cell cDNA library encodes a 540-amino acid protein precipitated by anti-phosphotyrosine. Northern blot analysis indicates that STAM is expressed as a 2.9-kb message in a wide variety of tissue and cell types. The STAM sequence contains a Src-homology 3 (SH3) domain and an immunoreceptor tyrosine-based activation motif (ITAM). It has been suggested that STAM acts as an adaptor molecule in signal transduction pathways from cytokine receptors.
Research Articles on Signal Transducing Adaptor Molecule (STAM)
| Target | Signal Transducing Adaptor Molecule (STAM) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 326-356 amino acids from the C-terminal region of human STAM. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q92783 (UniProt, ExPASy) |
| UniProt Secondary AC | B0YJ99, D3DRU5, Q8N6D9 |
| UniProt Entry Name | STAM1_HUMAN |
| KEGG | hsa:8027 |
| String | 9606.ENSP00000366746 |
| Molecular Weight | Calculated MW: 59.2 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse STAM. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |