Signal Transducing Adaptor Molecule (STAM) Antibody

Stimulation of cells with cytokines initiates a signal transduction cascade involving cytokine receptors, Janus kinases (JAKs) and signal transducers and activators of transcription (STATs). STAM for 'signal-transducing adaptor molecule, induced after stimulation of cells with cytokine IL2, is a component of signal transduction downstream of JAK3.1 Human STAM cDNA cloned from a T-cell cDNA library encodes a 540-amino acid protein precipitated by anti-phosphotyrosine. Northern blot analysis indicates that STAM is expressed as a 2.9-kb message in a wide variety of tissue and cell types. The STAM sequence contains a Src-homology 3 (SH3) domain and an immunoreceptor tyrosine-based activation motif (ITAM). It has been suggested that STAM acts as an adaptor molecule in signal transduction pathways from cytokine receptors.

Target	Signal Transducing Adaptor Molecule (STAM)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 326-356 amino acids from the C-terminal region of human STAM.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q92783 (UniProt, ExPASy)
UniProt Secondary AC	B0YJ99, D3DRU5, Q8N6D9
UniProt Entry Name	STAM1_HUMAN
KEGG	hsa:8027
String	9606.ENSP00000366746
Molecular Weight	Calculated MW: 59.2 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse STAM.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Signal Transducing Adaptor Molecule (STAM)

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