+44 (0) 1223 755950
+1 832 327 7413
Abelson Tyrosine-Protein Kinase 2 (ABL2) Antibody
REQUEST MORE INFO
Catalogue No: abx015718
Price:
US$427.75
(Size: 100 µl)
Orders to United States ship from United States
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
ABL2 (ARG, Abl-related gene), together with c-Abl, forms the Abl family of mammalian non-receptor tyrosine kinases.ABL2 and c-Abl share 89%, 90 and 93% identity in their SH3, SH2 and tyrosine domain, but only 29% identity in the carboxy-terminal half.The human c-Abl and ABL2 genes are expressed ubiquitously.ABL2 had been detected predominantly in the cytoplasm, whereas c-Abl shows both cytoplasmic and nuclear localization.c-Abl is involved in two different chromosomal translocations present in human leukemias, which generate Bcr-Abl and TEL-Abl.Recently, TEL-ARG fusion transcripts have also been identified in acute myeloid leukemias (AML).The Abl family kinases may also interact with receptor tyrosine signaling pathways and regulate cellular function such as cell cycle progression, gene transcription and organization of the actin cytoskeletons in neurons.
Research Articles on Abelson Tyrosine-Protein Kinase 2 (ABL2)
| Target | Abelson Tyrosine-Protein Kinase 2 (ABL2) |
| Clonality | Monoclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, IF/ICC |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of ABL2 expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P42684 (UniProt, ExPASy) |
| UniProt Entry Name | ABL2_HUMAN |
| Gene Symbol | ABL2 |
| GeneID | 27 |
| KEGG | hsa:27 |
| String | 9606.ENSP00000427562 |
| Enzyme Commission Number | EC 2.7.10.2 |
| Molecular Weight | 128 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |