Abelson Tyrosine-Protein Kinase 2 (ABL2) Antibody

ABL2 (ARG, Abl-related gene), together with c-Abl, forms the Abl family of mammalian non-receptor tyrosine kinases.ABL2 and c-Abl share 89%, 90 and 93% identity in their SH3, SH2 and tyrosine domain, but only 29% identity in the carboxy-terminal half.The human c-Abl and ABL2 genes are expressed ubiquitously.ABL2 had been detected predominantly in the cytoplasm, whereas c-Abl shows both cytoplasmic and nuclear localization.c-Abl is involved in two different chromosomal translocations present in human leukemias, which generate Bcr-Abl and TEL-Abl.Recently, TEL-ARG fusion transcripts have also been identified in acute myeloid leukemias (AML).The Abl family kinases may also interact with receptor tyrosine signaling pathways and regulate cellular function such as cell cycle progression, gene transcription and organization of the actin cytoskeletons in neurons.

Target	Abelson Tyrosine-Protein Kinase 2 (ABL2)
Clonality	Monoclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, IF/ICC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of ABL2 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P42684 (UniProt, ExPASy)
UniProt Entry Name	ABL2_HUMAN
Gene Symbol	ABL2
GeneID	27
KEGG	hsa:27
String	9606.ENSP00000427562
Enzyme Commission Number	EC 2.7.10.2
Molecular Weight	128 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Abelson Tyrosine-Protein Kinase 2 (ABL2)

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