+44 (0) 1223 755950
+1 832 327 7413
ABL (pY204) Antibody
REQUEST MORE INFO
Catalogue No: abx032003
Price:
US$326.25
(Size: 80 µl)
Orders to United States ship from United States
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
ABL1 is a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-ABL protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t (9;22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.
Research Articles on ABL (pY204)
| Target | ABL (pY204) |
| Clonality | Polyclonal |
| Target Modification | Tyr204 |
| Modification | Phosphorylation |
| Reactivity | Human |
| Tested Applications | ELISA, IF/ICC, DB |
| Host | Rabbit |
| Recommended dilutions | IF/ICC: 1/10 - 1/50, DB: 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y204 of human ABL. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P00519 (UniProt, ExPASy) |
| UniProt Secondary AC | A3KFJ3, Q13869, Q13870, Q16133, Q17R61, Q45F09 |
| UniProt Entry Name | ABL1_HUMAN |
| KEGG | hsa:25 |
| String | 9606.ENSP00000361423 |
| Molecular Weight | Calculated MW: 123 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse and Zebrafish ABL1. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |