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Arginase 1 (ARG1) Antibody
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Catalogue No: abx146617
Price:
US$406.00
(Size: 100 µg)
Orders to United States ship from United States
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Arginase 1 (ARG1) Antibody is a Rabbit Polyclonal antibody for the detection of ARG1. Arginase-1 (Liver arginase) belongs to the arginase family. ARG1 is a novel immunohistochemical marker of hepatocellular differentiation in fine needle aspiration cytology and a marker of hepatocytes and hepatocellular neoplasms. ARG1 is closely associated with alternative macrophage activation (PMID:12098359) and ARG1 has been shown to protectmotor neurons from trophic factor deprivation and allow sensory neurons to overcome neurite outgrowth inhibition by myelin proteins (PMID: 20071539).It can exsit as a homotrimer (PMID:16141327) and it has 3 isoforms produced by alternative splicing.Defects in ARG1 are the cause of argininemia (ARGIN). Deletion or TNF-mediated restriction of ARG1 unleashes the production of NO by NOS2, which is critical for pathogen control. (PMID:27117406).
Research Articles on Arginase 1 (ARG1)
| Target | Arginase 1 (ARG1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IF/ICC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | arginase, liver |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P05089 (UniProt, ExPASy) |
| UniProt Secondary AC | A6NEA0, Q5JWT5, Q5JWT6, Q8TE72, Q9BS50 |
| Gene Symbol | ARG1 |
| GeneID | 383 |
| OMIM | 207800 |
| NCBI Accession | NP_000036.2 |
| HGNC | 663 |
| Ensembl | ENSG00000118520 |
| Molecular Weight | Observed MW: 25-40 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |