Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) Antibody

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.

Target	Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 605-632 amino acids from the Central region of human ARHGEF11.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O15085 (UniProt, ExPASy)
UniProt Secondary AC	D3DVD0, Q5VY40, Q6PFW2
UniProt Entry Name	ARHGB_HUMAN
Gene Symbol	ARHGEF11
KEGG	hsa:9826
String	9606.ENSP00000357177
Molecular Weight	Calculated MW: 168 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat ARHGEF11.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11)

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