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B-Cell Lymphoma/leukemia 10 (BCL10) Antibody
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Catalogue No: abx001024
Price:
US$377.00
(Size: 60 µl)
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BCL10 Antibody is a Rabbit Polyclonal antibody against BCL10. This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
Research Articles on B-Cell Lymphoma/leukemia 10 (BCL10)
| Target | B-Cell Lymphoma/leukemia 10 (BCL10) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human BCL10 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O95999 (UniProt, ExPASy) |
| UniProt Secondary AC | Q5VUF1 |
| UniProt Entry Name | BCL10_HUMAN |
| Gene Symbol | BCL10 |
| GeneID | 8915 |
| NCBI Accession | NP_003912.1 |
| KEGG | hsa:8915 |
| String | 9606.ENSP00000359612 |
| Molecular Weight | Calculated MW: 26 kDa Observed MW: 33 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
