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Caspase 1 (CASP1) Antibody
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Catalogue No: abx000918
Price:
US$348.00
(Size: 60 µl)
Orders to United States ship from United States
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CASP1 Antibody is a Rabbit Polyclonal antibody against CASP1. This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
Research Articles on Caspase 1 (CASP1)
| Target | Caspase 1 (CASP1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human Caspase-1 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P29466 (UniProt, ExPASy) |
| UniProt Secondary AC | B5MDZ1, Q53EY6, Q6DMQ1, Q6GSS3, Q6PI75, Q9UCN3 |
| UniProt Entry Name | CASP1_HUMAN |
| Gene Symbol | CASP1 |
| GeneID | 834 |
| NCBI Accession | NP_150634.1 |
| KEGG | hsa:834 |
| String | 9606.ENSP00000433138 |
| Molecular Weight | Calculated MW: 10 kDa/29 kDa/35 kDa/42 kDa/45 kDa Observed MW: 48 kDa |
| Buffer | PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
