C-C Motif Chemokine 4 (CCL4) Antibody

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Catalogue No: abx001404
Price: US$348.00
(Size: 60 µl)

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C-C Motif Chemokine 4 (CCL4) Antibody

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Datasheet SDS
CCL4 Antibody is a Rabbit Polyclonal antibody against CCL4. Chemokines are members of a superfamily of small inducible, secreted, pro-inflammatory cytokines. Members of the chemokine family exhibit 20 to 50% homology in their predicted amino acid sequences and are divided into four subfamilies. In C-C (or b) subfamily, the first two cysteines are adjacent. C-C chemokines are chemoattractants and activators for monocytes and T cells. C-C subfamily members include macrophage inflammatory protein (MIP)-1å, MIP-1∫, MIP-2, MIP-3å, MIP-3∫, MIP-4, HCC-1, MIP-5 (or HCC-2), RANTES, MCP-1/2/3 (and the murine homologs JE and MARC), I-309, murine C10 and TCA3. Research has shown that MIP-1∫ is more selective than MIP-1å, primarily attracting CD4+ T lymphocytes, with a preference for T cells of the naive phenotype. MIP-1å is a more potent lymphocyte chemoattractant than MIP-1∫ and exhibits a broader range of chemoattractant specificities. It has been suggested that CD8+ T lymphocytes are involved in the control of HIV infection in vivo by the release of HIV-suppressive factors (HIV-SF). MIP-1å has been identified as one of the major HIV-SFs produced by CD8+ T cells, along with MIP-1∫ and RANTES. Recombinant human MIP-1å acts as an inhibitor of different strains of HIV-1, HIV-2 and SIV infection in a dose-dependent manner.

Target C-C Motif Chemokine 4 (CCL4)
Research Area Immunology, Infection Immunity
Clonality Polyclonal
Reactivity Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide corresponding to human CCL4
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P13236 (UniProt, ExPASy)
UniProt Secondary AC P22617, Q13704, Q3SXL8, Q6FGI8
UniProt Entry Name CCL4_HUMAN
Gene Symbol CCL4
GeneID 6351
NCBI Accession NP_002975.1
KEGG hsa:388372 hsa:6351
String 9606.ENSP00000482259
Molecular Weight Calculated MW: 10 kDa
Observed MW: 12 kDa
Buffer PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration 1 mg/ml
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on C-C Motif Chemokine 4 (CCL4)


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