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Serine/Threonine-Protein Kinase DCLK2 (DCLK2) Antibody
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Catalogue No: abx031317
Price:
US$326.25
(Size: 80 µl)
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This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified.
Research Articles on Serine/Threonine-Protein Kinase DCLK2 (DCLK2)
| Target | Serine/Threonine-Protein Kinase DCLK2 (DCLK2) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 167-196 amino acids from the N-terminal region of human DCLK2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q8N568 (UniProt, ExPASy) |
| UniProt Secondary AC | C9J5Q9, Q59GC8, Q8N399 |
| UniProt Entry Name | DCLK2_HUMAN |
| Gene Symbol | DCLK2 |
| GeneID | 166614 |
| OMIM | 613166 |
| HGNC | 19002 |
| KEGG | hsa:166614 |
| Ensembl | ENSG00000170390 |
| String | 9606.ENSP00000303887 |
| Molecular Weight | Calculated MW: 83.6 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |