DEFB121 Antibody is a Rabbit Polyclonal antibody against DEFB121. ∫-defensins (also designated BDs, or hBDs in human) are small cationic peptides with broad-spectrum antimicrobial activity against a variety of enveloped viruses, fungi and bacteria. Produced in mucosal epithelia and neutrophils of several species, ∫-defensins are developmentally regulated. The family of ∫-defensin proteins share a common defensin-motif that is characterized by multiple cysteine residues and a highly conserved tertiary structure. Besides playing a significant role in host immune defense, many ∫-defensins also are involved in sperm maturation and capacitation. ∫-defensin 121 is a 76 amino acid secreted protein that most likely contains a signal peptide sequence that requires cleavage by proteolytic enzymes in order to become biologically active. While expressed at low levels in testis, ∫-defensin 121 is abundantly expressed in epididymal caput and corpus and, unlike other ∫-defensins, it does not appear to be regulated by androgens.

Target	Defensin Beta 121 (DEFB121)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	IHC, IF/ICC
Host	Rabbit
Recommended dilutions	IHC-P: 1/50 - 1/100, IF/ICC: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein corresponding to human DEFB121
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q5J5C9 (UniProt, ExPASy)
UniProt Secondary AC	A1L4N1
UniProt Entry Name	DB121_HUMAN
Gene Symbol	DEFB121
GeneID	245934
NCBI Accession	NP_001011878.1
KEGG	hsa:245934
String	9606.ENSP00000417128
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	1 mg/ml
Availability	Shipped within 5-10 working days.
Note	THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Research Articles on Defensin Beta 121 (DEFB121)

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