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Defensin Beta 121 (DEFB121) Antibody

Catalogue No: abx001120
Price: £120.00
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DEFB121 Antibody is a Rabbit Polyclonal antibody against DEFB121. ∫-defensins (also designated BDs, or hBDs in human) are small cationic peptides with broad-spectrum antimicrobial activity against a variety of enveloped viruses, fungi and bacteria. Produced in mucosal epithelia and neutrophils of several species, ∫-defensins are developmentally regulated. The family of ∫-defensin proteins share a common defensin-motif that is characterized by multiple cysteine residues and a highly conserved tertiary structure. Besides playing a significant role in host immune defense, many ∫-defensins also are involved in sperm maturation and capacitation. ∫-defensin 121 is a 76 amino acid secreted protein that most likely contains a signal peptide sequence that requires cleavage by proteolytic enzymes in order to become biologically active. While expressed at low levels in testis, ∫-defensin 121 is abundantly expressed in epididymal caput and corpus and, unlike other ∫-defensins, it does not appear to be regulated by androgens.

Target DEFB121
Clonality Polyclonal
Reactivity Human
Tested Applications IHC
Host Rabbit
Recommended dilutions IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human DEFB121.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q5J5C9 (UniProt, ExPASy)
UniProt Secondary AC A1L4N1
UniProt Entry Name DB121_HUMAN
Gene Symbol DEFB121
GeneID 245934
KEGG hsa:24593
String 9606.ENSP00000417128
Molecular Weight Calculated MW: 8 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Defensin Beta 121 (DEFB121) Antibody

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