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DNA Methyltransferase 3 Beta (Dnmt3b) Antibody
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Catalogue No: abx025686
Price:
US$326.25
(Size: 80 µl)
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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. Dnmt3b is a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome.
Research Articles on DNA Methyltransferase 3 Beta (Dnmt3b)
| Target | DNA Methyltransferase 3 Beta (Dnmt3b) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/2000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 389-417 amino acids from human Dnmt3b. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9UBC3 (UniProt, ExPASy) |
| UniProt Entry Name | DNM3B_HUMAN |
| NCBI Accession | NP_001193984.1 NP_001193985.1 NP_008823.1 NP_787044.1 NP_787045.1 NP_787046.1 |
| String | 9606.ENSP00000328547 |
| Molecular Weight | Calculated MW: 95.8 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |