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Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A) Antibody
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Catalogue No: abx033472
Price:
US$326.25
(Size: 80 µl)
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DYRK1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. The DYRK1A gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome.
Research Articles on Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A)
| Target | Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 107-136 amino acids from the N-terminal region of human DYRK1A. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q13627 (UniProt, ExPASy) |
| UniProt Secondary AC | O60769, Q92582, Q92810, Q9UNM5 |
| UniProt Entry Name | DYR1A_HUMAN |
| KEGG | hsa:1859 |
| String | 9606.ENSP00000381932 |
| Molecular Weight | Calculated MW: 85.6 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Rat and Xenopus DYRK1A. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |