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ERBB3 (pY1289) Antibody
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Catalogue No: abx032081
Price:
US$326.25
(Size: 80 µl)
Orders to United States ship from United States
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This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form.
Research Articles on ERBB3 (pY1289)
| Target | ERBB3 (pY1289) |
| Clonality | Polyclonal |
| Target Modification | Tyr1289 |
| Modification | Phosphorylation |
| Reactivity | Human |
| Tested Applications | ELISA, WB, DB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, DB: 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1289 of human ERBB3. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P21860 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K6L6, B4DIK7, B4DV32, E9PDT8, Q9BUD7 |
| UniProt Entry Name | ERBB3_HUMAN |
| NCBI Accession | NP_001005915.1 NP_001973.2 |
| KEGG | hsa:2065 |
| String | 9606.ENSP00000267101 |
| Molecular Weight | Calculated MW: 148 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |