ESPL1 (pS1126) Antibody

ESPL1 (pS1126) Antibody is a Rabbit Polyclonal antibody against ESPL1 (pS1126). Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids.

Target	ESPL1 (pS1126)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic phosphorylated peptide around S1126 of human ESPL1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q14674 (UniProt, ExPASy)
UniProt Entry Name	ESPL1_HUMAN
Gene Symbol	ESPL1
GeneID	9700
NCBI Accession	NP_036423.4
KEGG	hsa:9700
String	9606.ENSP00000257934
Molecular Weight	Calculated MW: 233 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on ESPL1 (pS1126)

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