Dimethylaniline Monooxygenase [N-Oxide-Forming] 3 (FMO3) Antibody

Catalogue No: abx001558
Price: £120.00
(Size: 20 µl)
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Dimethylaniline Monooxygenase [N-Oxide-Forming] 3 (FMO3) Antibody

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FMO3 Antibody is a Rabbit Polyclonal antibody against FMO3. Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.

Target FMO3
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human FMO3.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P31513 (UniProt, ExPASy)
UniProt Secondary AC B2R816, Q14854, Q8N5N5
UniProt Entry Name FMO3_HUMAN
Gene Symbol FMO3
GeneID 2328
KEGG hsa:2328
String 9606.ENSP00000356729
Molecular Weight Calculated MW: 60 kDa
Observed MW: 68 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Dimethylaniline Monooxygenase [N-Oxide-Forming] 3 (FMO3) Antibody

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