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Transcription Factor Jun (JUN) Antibody
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Catalogue No: abx000631
Price:
US$217.50
(Size: 20 µl)
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Transcription Factor Jun (JUN) Antibody is a Rabbit Polyclonal antibody against Transcription Factor Jun (JUN). Transcription Factor Transcription Factor Jun (JUN) (Transcription Factor Jun (JUN)) is a member of the Transcription Factor Jun (JUN) Family containing Transcription Factor Transcription Factor Jun (JUN) (Transcription Factor Jun (JUN)), Transcription Factor Jun (JUN)B and Transcription Factor Jun (JUN)D, and is a component of the Transcription Factor Transcription Factor Jun (JUN) (activator protein-1). AP-1 is composed of dimers of Fos, Transcription Factor Jun (JUN) and ATF family members and binds to and activates transcription at TRE/AP-1 elements (reviewed in 1). Extracellular signals including growth factors, chemokines and stress activate AP-1-dependent transcription. The transcriptional activity of Transcription Factor Transcription Factor Jun (JUN) (Transcription Factor Jun (JUN)) is regulated by phosphorylation at Ser63 and Ser73 through SAPK/JNK (reviewed in 2). Knock-out studies in mice have shown that Transcription Factor Transcription Factor Jun (JUN) (Transcription Factor Jun (JUN)) is essential for embryogenesis (3), and subsequent studies have demonstrated roles for Transcription Factor Transcription Factor Jun (JUN) (Transcription Factor Jun (JUN)) in various tissues and developmental processes including axon regeneration (4), liver regeneration (5) and T cell development (6). AP-1 regulated genes exert diverse biological functions including cell proliferation, differentiation, and apoptosis, as well as transformation, invasion and metastasis, depending on cell type and context (7-9). Other target genes regulate survival as well as hypoxia and angiogenesis (8,10). Transcription Factor Transcription Factor Jun (JUN) (Transcription Factor Jun (JUN)) has emerged as a promising therapeutic target for cancer, vascular remodeling, acute inflammation, as well as rheumatoid arthritis (11,12).
Research Articles on Transcription Factor Jun (JUN)
| Target | Transcription Factor Jun (JUN) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 90-230 of c-Jun. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P05412 (UniProt, ExPASy) |
| UniProt Secondary AC | Q6FHM7, Q96G93 |
| UniProt Entry Name | JUN_HUMAN |
| Gene Symbol | JUN |
| GeneID | 3725 |
| OMIM | 165160 |
| NCBI Accession | NP_002219.1 |
| HGNC | 6204 |
| KEGG | hsa:3725 |
| Ensembl | ENSG00000177606 |
| String | 9606.ENSP00000360266 |
| Molecular Weight | Calculated MW: 36 kDa Observed MW: 46/42 kDa |
| Buffer | PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |