Transcription Factor Jun (Jun) Antibody

Transcription Factor Jun (Jun) Antibody is a Rabbit Polyclonal antibody against Transcription Factor Jun (Jun). Transcription Factor Transcription Factor Jun (Jun) (Transcription Factor Jun (Jun)) is a member of the Transcription Factor Jun (Jun) Family containing Transcription Factor Transcription Factor Jun (Jun) (Transcription Factor Jun (Jun)), Transcription Factor Jun (Jun)B and Transcription Factor Jun (Jun)D, and is a component of the Transcription Factor Transcription Factor Jun (Jun) (activator protein-1). AP-1 is composed of dimers of Fos, Transcription Factor Jun (Jun) and ATF family members and binds to and activates transcription at TRE/AP-1 elements (reviewed in 1). Extracellular signals including growth factors, chemokines and stress activate AP-1-dependent transcription. The transcriptional activity of Transcription Factor Transcription Factor Jun (Jun) (Transcription Factor Jun (Jun)) is regulated by phosphorylation at Ser63 and Ser73 through SAPK/JNK (reviewed in 2). Knock-out studies in mice have shown that Transcription Factor Transcription Factor Jun (Jun) (Transcription Factor Jun (Jun)) is essential for embryogenesis (3), and subsequent studies have demonstrated roles for Transcription Factor Transcription Factor Jun (Jun) (Transcription Factor Jun (Jun)) in various tissues and developmental processes including axon regeneration (4), liver regeneration (5) and T cell development (6). AP-1 regulated genes exert diverse biological functions including cell proliferation, differentiation, and apoptosis, as well as transformation, invasion and metastasis, depending on cell type and context (7-9). Other target genes regulate survival as well as hypoxia and angiogenesis (8,10). Transcription Factor Transcription Factor Jun (Jun) (Transcription Factor Jun (Jun)) has emerged as a promising therapeutic target for cancer, vascular remodeling, acute inflammation, as well as rheumatoid arthritis (11,12).

Target	Transcription Factor Jun (Jun)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 90-230 of c-Jun.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P05412 (UniProt, ExPASy)
UniProt Secondary AC	Q6FHM7, Q96G93
UniProt Entry Name	JUN_HUMAN
Gene Symbol	JUN
GeneID	3725
NCBI Accession	NP_002219.1
KEGG	hsa:3725
String	9606.ENSP00000360266
Molecular Weight	Calculated MW: 36 kDa Observed MW: 46/42 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Transcription Factor Jun (Jun)

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