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Leukocyte Cell Derived Chemotaxin 1 / LECT1 (CNMD) Antibody
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Catalogue No: abx005093
Price:
US$348.00
(Size: 60 µl)
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Leukocyte Cell Derived Chemotaxin 1 / LECT1 (CNMD) Antibody is a Rabbit Polyclonal antibody against Leukocyte Cell Derived Chemotaxin 1 / LECT1 (CNMD). This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms.
Research Articles on Leukocyte Cell Derived Chemotaxin 1 / LECT1 (CNMD)
| Target | Leukocyte Cell Derived Chemotaxin 1 / LECT1 (CNMD) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | IF/ICC |
| Host | Rabbit |
| Recommended dilutions | IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human LECT1 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O75829 (UniProt, ExPASy) |
| UniProt Secondary AC | Q5TAM4, Q8TAY6, Q9UM18 |
| UniProt Entry Name | CNMD_HUMAN |
| Gene Symbol | CNMD |
| GeneID | 11061 |
| NCBI Accession | NP_008946.1 |
| KEGG | hsa:11061 |
| String | 9606.ENSP00000367198 |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
