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Mesencephalic Astrocyte Derived Neurotrophic Factor (MANF) Antibody
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Catalogue No: abx005306
Price:
US$217.50
(Size: 20 µl)
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MANF Antibody is a Rabbit Polyclonal antibody against MANF. The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.
Research Articles on Mesencephalic Astrocyte Derived Neurotrophic Factor (MANF)
| Target | Mesencephalic Astrocyte Derived Neurotrophic Factor (MANF) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC, IF/ICC, IP |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200, IP: 0.5 µg - 4 µg antibody per 200 µg - 400 µg extracts of whole cells. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 25-182 of human ARMET/ARP/MANF. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P55145 (UniProt, ExPASy) |
| UniProt Secondary AC | Q14CX4, Q86U67, Q96IS4 |
| UniProt Entry Name | MANF_HUMAN |
| Gene Symbol | MANF |
| GeneID | 7873 |
| NCBI Accession | NP_006001.5 |
| KEGG | hsa:7873 |
| String | 9606.ENSP00000432799 |
| Molecular Weight | Calculated MW: 21 kDa Observed MW: 16 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |