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Methyl-CpG Binding Domain Protein 2 (MBD2) Antibody
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Catalogue No: abx025844
Price:
US$326.25
(Size: 80 µl)
Orders to United States ship from United States
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DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.
Research Articles on Methyl-CpG Binding Domain Protein 2 (MBD2)
| Target | Methyl-CpG Binding Domain Protein 2 (MBD2) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 120-151 amino acids from the N-terminal region of human MBD2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9UBB5 (UniProt, ExPASy) |
| UniProt Secondary AC | O95242, Q9UIS8 |
| UniProt Entry Name | MBD2_HUMAN |
| NCBI Accession | NP_003918.1 NP_056647.1 |
| String | 9606.ENSP00000256429 |
| Molecular Weight | Calculated MW: 43.3 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |