PR Domain Zinc Finger Protein 2 (PRDM2) Antibody

This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene.

Target	PR Domain Zinc Finger Protein 2 (PRDM2)
Clonality	Monoclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, ChIP
Host	Mouse
Recommended dilutions	WB: 1/1000, ChIP: 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant GST fusion protein encoding 1-347 AA of human PRDM2 (RIZ1).
Isotype	IgG1
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q13029 (UniProt, ExPASy)
UniProt Secondary AC	B1AJZ4, B5MC68, Q13149, Q14550, Q5THJ1, Q5VUL9
UniProt Entry Name	PRDM2_HUMAN
NCBI Accession	NP_001007258.1 NP_001129082.1 NP_036363.2 NP_056950.2
KEGG	hsa:7799
String	9606.ENSP00000235372
Molecular Weight	Calculated MW: 189 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	This antibody is specific for RIZ1, it does not recognise the isoform beta (RIZ2).
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on PR Domain Zinc Finger Protein 2 (PRDM2)

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