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RAD50 Double Strand Break Repair Protein (RAD50) Antibody
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Catalogue No: abx002219
Price:
US$348.00
(Size: 60 µl)
Orders to United States ship from United States
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RAD50 Antibody is a Rabbit Polyclonal antibody against RAD50. The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.
Research Articles on RAD50 Double Strand Break Repair Protein (RAD50)
| Target | RAD50 Double Strand Break Repair Protein (RAD50) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide corresponding to human RAD50 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q92878 (UniProt, ExPASy) |
| UniProt Secondary AC | B9EGF5, O43254, Q6GMT7, Q6P5X3, Q9UP86 |
| UniProt Entry Name | RAD50_HUMAN |
| Gene Symbol | RAD50 |
| GeneID | 10111 |
| NCBI Accession | NP_005723.2 |
| KEGG | hsa:10111 |
| String | 9606.ENSP00000368100 |
| Molecular Weight | Calculated MW: 138 kDa/153 kDa/154 kDa Observed MW: 180 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
