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RAD50 Double Strand Break Repair Protein (RAD50) Antibody

Catalogue No: abx002219
Price: £120.00
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RAD50 Double Strand Break Repair Protein (RAD50) Antibody RAD50 Double Strand Break Repair Protein (RAD50) Antibody

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RAD50 Antibody is a Rabbit Polyclonal antibody against RAD50. The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.

Target RAD50
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IP
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IP: 1/20 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide of human RAD50.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q92878 (UniProt, ExPASy)
UniProt Secondary AC B9EGF5, O43254, Q6GMT7, Q6P5X3, Q9UP86
UniProt Entry Name RAD50_HUMAN
Gene Symbol RAD50
GeneID 10111
KEGG hsa:10111
String 9606.ENSP00000368100
Molecular Weight Calculated MW: 138 kDa, 153 kDa, 154 kDa
Observed MW: 170 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on RAD50 Double Strand Break Repair Protein (RAD50) Antibody

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