+44 (0) 1223 755950
+1 832 327 7413
Runt-Related Transcription Factor 2 (RUNX2) Antibody
REQUEST MORE INFO
Catalogue No: abx033650
Price:
US$326.25
(Size: 80 µl)
Orders to United States ship from United States
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
Runx2 is a member of the RUNX family of transcription factors. It is a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. It can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in the Runx2 gene have been associated with the bone development disorder cleidocranial dysplasia (CCD).
Research Articles on Runt-Related Transcription Factor 2 (RUNX2)
| Target | Runt-Related Transcription Factor 2 (RUNX2) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/2000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 445-474 amino acids surrounding S533 of human RUNX2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q13950 (UniProt, ExPASy) |
| UniProt Secondary AC | O14614, O14615, O95181 |
| UniProt Entry Name | RUNX2_HUMAN |
| NCBI Accession | NP_001015051.3 NP_001019801.3 |
| KEGG | hsa:860 |
| String | 9606.ENSP00000360493 |
| Molecular Weight | Calculated MW: 56.6 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |