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Sirtuin 1 (SirT1) Antibody
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Catalogue No: abx012039
Price:
US$406.00
(Size: 100 µg)
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Sirtuin 1 (SirT1) Antibody is a Rabbit Polyclonal antibody for the detection of SIRT1. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
Research Articles on Sirtuin 1 (SirT1)
| Target | Sirtuin 1 (SirT1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | sirtuin (silent mating type information regulation 2 homolog) 1 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | Q96EB6 (UniProt, ExPASy) |
| UniProt Secondary AC | Q2XNF6, Q5JVQ0, Q9GZR9, Q9Y6F0 |
| UniProt Entry Name | SIR1_HUMAN |
| Gene Symbol | SIRT1 |
| GeneID | 23411 |
| OMIM | 604479 |
| HGNC | 14929 |
| KEGG | hsa:23411 |
| Ensembl | ENSG00000096717 |
| String | 9606.ENSP00000212015 |
| Enzyme Commission Number | EC 3.5.1.- |
| Molecular Weight | Observed MW: 130 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |