Splicing Factor 3A Subunit 1 (SF3A1) Antibody

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Catalogue No: abx003281
Price: US$217.50
(Size: 20 µl)

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Splicing Factor 3A Subunit 1 (SF3A1) Antibody

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Datasheet SDS
SF3A1 Antibody is a Rabbit Polyclonal antibody against SF3A1. This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.

Target Splicing Factor 3A Subunit 1 (SF3A1)
Clonality Polyclonal
Reactivity Mouse, Rat
Tested Applications ELISA, WB
Host Rabbit
Recommended dilutions ELISA: 1 µg/ml, WB: 1/1000 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 715-785 of human SF3A1.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q15459 (UniProt, ExPASy)
UniProt Secondary AC E9PAW1
UniProt Entry Name SF3A1_HUMAN
GeneID 10291
KEGG hsa:10291
String 9606.ENSP00000215793
Molecular Weight Calculated MW: 89 kDa
Observed MW: 130 kDa
Buffer PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration > 0.2 mg/ml
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on Splicing Factor 3A Subunit 1 (SF3A1)


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