Signal Transducer and Activator of Transcription 6 Phospho-Tyr641 (STAT6 pY641) Antibody

STAT6 (pY641) Antibody is a Rabbit Polyclonal antibody against STAT6 (pY641). The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.

Target	Signal Transducer and Activator of Transcription 6 Phospho-Tyr641 (STAT6 pY641)
Clonality	Polyclonal
Target Modification	Tyr641
Modification	Phosphorylation
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic phosphorylated peptide around Y641 of human STAT6.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P42226 (UniProt, ExPASy)
UniProt Secondary AC	A8K316, B7ZA27, F5GXI9, Q5FBW5, Q71UP4
Gene Symbol	STAT6
GeneID	6778
NCBI Accession	NP_003144.3
Molecular Weight	Calculated MW: 94 kDa Observed MW: 110 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Signal Transducer and Activator of Transcription 6 Phospho-Tyr641 (STAT6 pY641)

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