Signal Transducer and Activator of Transcription 6 Phospho-Tyr641 (STAT6 pY641) Antibody

Catalogue No: abx000503
Price: £230.00
(Size: 50 µl)

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Datasheet SDS
STAT6 (pY641) Antibody is a Rabbit Polyclonal antibody against STAT6 (pY641). The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.

Target Signal Transducer and Activator of Transcription 6 Phospho-Tyr641 (STAT6 pY641)
Clonality Polyclonal
Target Modification Tyr641
Modification Phosphorylation
Reactivity Human
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Y641 of human STAT6.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P42226 (UniProt, ExPASy)
UniProt Secondary AC A8K316, B7ZA27, F5GXI9, Q5FBW5, Q71UP4
Gene Symbol STAT6
GeneID 6778
Molecular Weight Calculated MW: 74 kDa, 81 kDa, 94 kDa
Observed MW: 110 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Signal Transducer and Activator of Transcription 6 Phospho-Tyr641 (STAT6 pY641)

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