STEP / PTPN5 Antibody

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Catalogue No: abx033947
Price: US$326.25
(Size: 80 µl)

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STEP / PTPN5 Antibody STEP / PTPN5 Antibody STEP / PTPN5 Antibody

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Datasheet SDS
STEP (striatum-enriched phosphatase) is a neural-specific protein-tyrosine phosphatase, first isolated from the rat brain. The 537-amino acid predicted human protein as isolated from cDNA sequences is between 85 and 90% identical to the mouse and rat sequences. In rat neuronal cell cultures, glutamate-mediated activation of N-methyl-D-aspartate (NMDA) receptors leads to the rapid but transient phosphorylation of extracellular signal-related kinase-2 (ERK2). NMDA-mediated influx of calcium, activates the calcium-dependent phosphatase calcineurin and the resulting dephosphorylation and activation of STEP. STEP then inactivatea ERK2 through tyrosine dephosphorylation and blocks translocation of the kinase to the nucleus. STEP plays a significant role in regulating the ERK activation and downstream signaling in neurons.

Target STEP/PTPN5
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications ELISA, WB, IHC
Host Rabbit
Recommended dilutions WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic peptide between 168-198 amino acids from the N-terminal region of human STEP / PTPN5.
Isotype IgG
Form Liquid
Purification Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P54829 (UniProt, ExPASy)
UniProt Secondary AC B3KXG7, B7Z386, B7ZAF5, D3DQY7, Q6P1Z2, Q8N2A1, Q8NDP8
UniProt Entry Name PTN5_HUMAN
NCBI Accession NP_001035059.1 NP_001265165.1 NP_001265167.1 NP_001265168.1 NP_008837.1 NP_116170.3
KEGG hsa:84867
String 9606.ENSP00000351342
Molecular Weight Calculated MW: 63.5 kDa
Buffer PBS containing 0.09% sodium azide.
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on STEP/PTPN5


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