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Small Ubiquitin Related Modifier Protein 2 (SUMO2) Antibody
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Catalogue No: abx034921
Price:
US$326.25
(Size: 80 µl)
Orders to United States ship from United States
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Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.
Research Articles on Small Ubiquitin Related Modifier Protein 2 (SUMO2)
| Target | Small Ubiquitin Related Modifier Protein 2 (SUMO2) |
| Clonality | Monoclonal |
| Reactivity | Human, Rat |
| Tested Applications | ELISA, WB, IF/ICC |
| Host | Mouse |
| Recommended dilutions | WB: 1/1000, IF/ICC: 1/25. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified His-tagged Human SUMO2 protein |
| Isotype | IgG2b |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P61956 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R4I2, P55855, Q32Q42, Q6IPZ6, Q96HK1 |
| NCBI Accession | NP_001005849.1 NP_008868.3 |
| KEGG | hsa:6613 |
| Molecular Weight | Calculated MW: 10.9 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Cow, Pig, Chicken, Hamster and Monkey SUMO2. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |