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E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
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Catalogue No: abx025098
Price:
US$326.25
(Size: 80 µl)
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HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. Synoviolin/Hrd1 (expressed in rheumatoid synovium) is reported to be a novel causative factor for arthropathy by triggering synovial cell outgrowth through its antiapoptotic effects. HRD1 contains one ring-type zinc finger.
Research Articles on E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1)
| Target | E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 58-88 amino acids from the N-terminal region of human SYVN1 (HRD1). |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q86TM6 (UniProt, ExPASy) |
| UniProt Secondary AC | Q8N3K3, Q8N6E8, Q96JL5, Q96PK3 |
| UniProt Entry Name | SYVN1_HUMAN |
| NCBI Accession | NP_115807.1 NP_757385.1 |
| KEGG | hsa:84447 |
| String | 9606.ENSP00000366395 |
| Molecular Weight | Calculated MW: 67.7 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse and Xenopus SYVN1. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |