+44 (0) 1223 755950
+1 832 327 7413
Toll Like Receptor Adaptor Molecule 1 (TICAM1) Antibody
REQUEST MORE INFO
Catalogue No: abx117043
Price:
US$522.00
(Size: 100 µl)
Orders to United States ship from United States
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
TICAM1 Antibody is a Rabbit Polyclonal antibody against TICAM1. Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responsesTLRs recognize conserved motifs found in various pathogens and mediate defense responsesTriggering of the TLR pathway leads to the activation of NF-κB and subsequent regulation of immune and inflammatory genesThe TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the TIR domainUpon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule)This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKKActivation of IKK leads to the degradation of IκB that normally maintains NF-κB inactivity by sequestering it in the cytoplasmTRIF (also termed TICAM-1) is a TIR-domain adaptor protein described to activate NF-κB, IRF3 and trigger IFN-β productionStudies using dominant negative forms of TRIF and siRNA targeting TRIF show that TRIF functions downstream of both TLR3 and TLR4 in response to dsRNA and LPS respectivelyTRIF recruits TRAF6-TAK1-TAB2 to the receptor complex which leads to NF-κB activationIn addition, TRIF can trigger signaling of that lead to the induction of apoptosis.
Research Articles on Toll Like Receptor Adaptor Molecule 1 (TICAM1)
| Target | Toll Like Receptor Adaptor Molecule 1 (TICAM1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant protein of human TICAM1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q8IUC6 (UniProt, ExPASy) |
| UniProt Secondary AC | B3Y691, O75532, Q86XP8, Q96GA0 |
| UniProt Entry Name | TCAM1_HUMAN |
| Gene Symbol | TICAM1 |
| GeneID | 148022 |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |